Seminal fluid is often viewed as simply a vehicle to carry sperm to fertilize the oocyte, but a
more complex function in influencing female reproductive physiology is now evident.
Remarkably, seminal fluid contains soluble and exosome-born signaling agents that interact
with the female reproductive tract to prime the immune response, with consequences for
fertility and pregnancy outcome. Experiments in rodent models demonstrate a key role for
seminal fluid in enabling robust embryo implantation and optimal placental development. In …