Cumulative exposure to paternal seminal fluid prior to conception and subsequent risk of preeclampsia
AF Saftlas, L Rubenstein, K Prater, KK Harland… - Journal of reproductive …, 2014 - Elsevier
A growing body of literature suggests that prior and prolonged exposure to paternal antigens
in seminal fluid induces maternal tolerance to the allogeneic fetus, protecting it from
rejection and facilitating successful implantation and placentation. In this case–control study
of nulliparous women, we test the hypothesis that increased exposure to paternal seminal
fluid via the vaginal or oral route will confer a reduced risk of preeclampsia. Preeclampsia
cases (n= 258) and normotensive controls (n= 182) were selected from live births to Iowa …
in seminal fluid induces maternal tolerance to the allogeneic fetus, protecting it from
rejection and facilitating successful implantation and placentation. In this case–control study
of nulliparous women, we test the hypothesis that increased exposure to paternal seminal
fluid via the vaginal or oral route will confer a reduced risk of preeclampsia. Preeclampsia
cases (n= 258) and normotensive controls (n= 182) were selected from live births to Iowa …