Characterization of regulatory T cells in decidua of miscarriage cases with abnormal or normal fetal chromosomal content
K Inada, T Shima, A Nakashima, K Aoki, M Ito… - Journal of reproductive …, 2013 - Elsevier
Decreased regulatory T (Treg) cells have been reported in cases of recurrent pregnancy
loss. To understand the role of Treg cells in human pregnancy, we have studied the
frequency, localization and characterization of Treg cells in the decidua. The frequency of
Foxp3+ cells among CD3+ CD8− cells at the decidua basalis in cases of miscarriage with a
normal embryo karyotype (n= 10) was significantly lower than in normally progressing
pregnancies (n= 10). However, those frequencies in miscarriage with an abnormal embryo …
loss. To understand the role of Treg cells in human pregnancy, we have studied the
frequency, localization and characterization of Treg cells in the decidua. The frequency of
Foxp3+ cells among CD3+ CD8− cells at the decidua basalis in cases of miscarriage with a
normal embryo karyotype (n= 10) was significantly lower than in normally progressing
pregnancies (n= 10). However, those frequencies in miscarriage with an abnormal embryo …