[HTML][HTML] Global Pregnancy Collaboration symposium: Prepregnancy and very early pregnancy antecedents of adverse pregnancy outcomes: Overview and …

JM Roberts, CWG Redman… - Placenta, 2017 - Elsevier
It is becoming increasingly evident that the origins of adverse pregnancy outcomes occur at
a far earlier time in gestation than has usually been considered in pathophysiological
studies of these conditions. To date most studies have addressed changes occurring at 10–
20 weeks menstrual age, the time of vascular remodeling of the spiral arteries supplying the
intervillus space. This is stimulated by the common pathophysiological changes identified in
these vessels in preeclampsia, fetal growth restriction, preterm birth, abruption and stillbirth …