The unique pathophysiology of early-onset severe preeclampsia: role of decidual T regulatory cells
KH Quinn, DY Lacoursiere, L Cui, J Bui… - Journal of reproductive …, 2011 - Elsevier
Immunological mechanisms play a pivotal role in the pathophysiology of preeclampsia. T
regulatory cells (Treg cells, FoxP3+) suppress the cytotoxic T cell (CD8+) and natural killer
(NK) cell response, thereby promoting immunological tolerance to the fetus. In peripheral
blood, Treg cells are elevated during pregnancy, decrease throughout gestation, and are
decreased in preeclampsia. To determine their role at the implantation site, we
characterized the proportion of decidual Treg and CD8+ cells, and compared these with …
regulatory cells (Treg cells, FoxP3+) suppress the cytotoxic T cell (CD8+) and natural killer
(NK) cell response, thereby promoting immunological tolerance to the fetus. In peripheral
blood, Treg cells are elevated during pregnancy, decrease throughout gestation, and are
decreased in preeclampsia. To determine their role at the implantation site, we
characterized the proportion of decidual Treg and CD8+ cells, and compared these with …