Endothelial cell metabolism: a novel player in atherosclerosis? Basic principles and therapeutic opportunities

A Pircher, L Treps, N Bodrug, P Carmeliet - Atherosclerosis, 2016 - Elsevier
Atherosclerosis is a leading cause of morbidity and mortality in Western society. Despite
improved insight into disease pathogenesis and therapeutic options, additional treatment
strategies are required. Emerging evidence highlights the relevance of endothelial cell (EC)
metabolism for angiogenesis, and indicates that EC metabolism is perturbed when ECs
become dysfunctional to promote atherogenesis. In this review, we overview the latest
insights on EC metabolism and discuss current knowledge on how atherosclerosis …