Removal of soluble fms-like tyrosine kinase-1 by dextran sulfate apheresis in preeclampsia
R Thadhani, H Hagmann… - Journal of the …, 2016 - journals.lww.com
Preeclampsia is a devastating complication of pregnancy. Soluble Fms-like tyrosine kinase-
1 (sFlt-1) is an antiangiogenic protein believed to mediate the signs and symptoms of
preeclampsia. We conducted an open pilot study to evaluate the safety and potential efficacy
of therapeutic apheresis with a plasma-specific dextran sulfate column to remove circulating
sFlt-1 in 11 pregnant women (20–38 years of age) with very preterm preeclampsia (23–32
weeks of gestation, systolic BP≥ 140 mmHg or diastolic BP≥ 90 mmHg, new onset …
1 (sFlt-1) is an antiangiogenic protein believed to mediate the signs and symptoms of
preeclampsia. We conducted an open pilot study to evaluate the safety and potential efficacy
of therapeutic apheresis with a plasma-specific dextran sulfate column to remove circulating
sFlt-1 in 11 pregnant women (20–38 years of age) with very preterm preeclampsia (23–32
weeks of gestation, systolic BP≥ 140 mmHg or diastolic BP≥ 90 mmHg, new onset …