[HTML][HTML] Greater transport efficiencies of the membrane fatty acid transporters FAT/CD36 and FATP4 compared with FABPpm and FATP1 and differential effects on …
JG Nickerson, H Alkhateeb, CR Benton, J Lally… - Journal of Biological …, 2009 - ASBMB
In selected mammalian tissues, long chain fatty acid transporters (FABPpm, FAT/CD36,
FATP1, and FATP4) are co-expressed. There is controversy as to whether they all function
as membrane-bound transporters and whether they channel fatty acids to oxidation and/or
esterification. Among skeletal muscles, the protein expression of FABPpm, FAT/CD36, and
FATP4, but not FATP1, correlated highly with the capacities for oxidative metabolism (r≥
0.94), fatty acid oxidation (r≥ 0.88), and triacylglycerol esterification (r≥ 0.87). We …
FATP1, and FATP4) are co-expressed. There is controversy as to whether they all function
as membrane-bound transporters and whether they channel fatty acids to oxidation and/or
esterification. Among skeletal muscles, the protein expression of FABPpm, FAT/CD36, and
FATP4, but not FATP1, correlated highly with the capacities for oxidative metabolism (r≥
0.94), fatty acid oxidation (r≥ 0.88), and triacylglycerol esterification (r≥ 0.87). We …