Genetic study of the CD36 gene in a French diabetic population
F Lepretre, KJ Linton, C Lacquemant, V Vatin… - Diabetes & …, 2004 - Elsevier
OBJECTIVES: CD36 is a multifunctional membrane receptor widely expressed in different
tissues which binds and internalizes oxidized low-density lipoprotein. In rodents, CD36 gene
variations modulate glucose homeostasis and contribute to metabolic syndrome associated
with type 2 diabetes but the effects in human are unknown. METHODS: We screened the
entire coding sequence of the CD36 gene in 272 individuals and we genotyped both rare
and frequent variants in 454 T2D subjects and 221 controls. RESULTS: We detected five …
tissues which binds and internalizes oxidized low-density lipoprotein. In rodents, CD36 gene
variations modulate glucose homeostasis and contribute to metabolic syndrome associated
with type 2 diabetes but the effects in human are unknown. METHODS: We screened the
entire coding sequence of the CD36 gene in 272 individuals and we genotyped both rare
and frequent variants in 454 T2D subjects and 221 controls. RESULTS: We detected five …