Age-related auditory pathology in the CBA/J mouse
SH Sha, A Kanicki, G Dootz, AE Talaska, K Halsey… - Hearing research, 2008 - Elsevier
Commercially obtained aged male CBA/J mice presented a complex pattern of hearing loss
and morphological changes. A significant threshold shift in auditory brainstem responses
(ABR) occurred at 3 months of age at 4kHz without apparent loss of hair cells, rising slowly
at later ages accompanied by loss of apical hair cells. A delayed high-frequency deficit
started at 24kHz around the age of 12 months. At 20–26 months, threshold shifts at 12 and
24kHz and the accompanying hair cell loss at the base of the cochlea were highly variable …
and morphological changes. A significant threshold shift in auditory brainstem responses
(ABR) occurred at 3 months of age at 4kHz without apparent loss of hair cells, rising slowly
at later ages accompanied by loss of apical hair cells. A delayed high-frequency deficit
started at 24kHz around the age of 12 months. At 20–26 months, threshold shifts at 12 and
24kHz and the accompanying hair cell loss at the base of the cochlea were highly variable …