Activity-dependent neuroprotective protein: a novel gene essential for brain formation
A Pinhasov, S Mandel, A Torchinsky, E Giladi… - Developmental Brain …, 2003 - Elsevier
We have recently cloned the novel homeobox-containing activity-dependent neuroprotective
protein (ADNP). In the current study, mouse ADNP was shown to be expressed at the time of
neural tube closure, detected at E7. 5 and increased on E9. 5. Expression was augmented
in the brain (E12. 5), sustained throughout embryogenesis and regulated by VIP. To assess
the function of ADNP, knockout mice were established. Detailed analysis revealed cranial
neural tube closure failure and death on E8. 5–9.0 of the ADNP-knockout embryos. The …
protein (ADNP). In the current study, mouse ADNP was shown to be expressed at the time of
neural tube closure, detected at E7. 5 and increased on E9. 5. Expression was augmented
in the brain (E12. 5), sustained throughout embryogenesis and regulated by VIP. To assess
the function of ADNP, knockout mice were established. Detailed analysis revealed cranial
neural tube closure failure and death on E8. 5–9.0 of the ADNP-knockout embryos. The …