[HTML][HTML] Activity-dependent neuroprotective protein constitutes a novel element in the SWI/SNF chromatin remodeling complex

S Mandel, I Gozes - Journal of Biological Chemistry, 2007 - ASBMB
Complete deficiency in activity-dependent neuroprotective protein (ADNP), a
heterochromatin 1-binding protein, results in dramatic changes in gene expression, neural
tube closure defects, and death at gestation day 9 in mice. To further understand the cellular
roles played by ADNP, the HEK293 human embryonic kidney cell line that allows efficient
transfection with recombinant DNA was used as a model for the identification of ADNP-
interacting proteins. Recombinant green fluorescent protein (GFP)-ADNP was localized to …