The role of the drebrin/EB3/Cdk5 pathway in dendritic spine plasticity, implications for Alzheimer's disease
PR Gordon-Weeks - Brain research bulletin, 2016 - Elsevier
Abstract The drebrin/EB3/Cdk5 intracellular signalling pathway couples actin filaments to
dynamic microtubules in cellular settings where cells are changing shape. The pathway has
been most intensively studied in neuronal development, particularly neuritogenesis and
neuronal migration, and in synaptic plasticity at dendritic spines in mature neurons. Drebrin
is an actin filament side-binding and bundling protein that stabilises actin filaments. The end-
binding (EB) proteins are microtubule plus-end tracking proteins (+ TIPs) that localise to the …
dynamic microtubules in cellular settings where cells are changing shape. The pathway has
been most intensively studied in neuronal development, particularly neuritogenesis and
neuronal migration, and in synaptic plasticity at dendritic spines in mature neurons. Drebrin
is an actin filament side-binding and bundling protein that stabilises actin filaments. The end-
binding (EB) proteins are microtubule plus-end tracking proteins (+ TIPs) that localise to the …
