[HTML][HTML] Role of proximal promoter elements in regulation of renin gene transcription

N Petrovic, TA Black, JR Fabian, C Kane… - Journal of Biological …, 1996 - ASBMB
Mouse As4. 1 cells, obtained after transgene-targeted oncogenesis to induce neoplasia in
renal renin-expressing cells, express high levels of renin mRNA from the endogenous Ren-
1 c gene. We have used these cells to characterize the role of the Ren-1 c proximal promoter
(+ 6 to-117) in the regulation of renin gene transcription. It was found that 4.1 kilobases (kb)
of Ren-1 c 5′-flanking sequence, in combination with the proximal promoter, are required
for strong activation (~ 2 orders of magnitude over the basal level of the promoter alone) of …