Ren1c homozygous null mice are hypotensive and polyuric, but heterozygotes are indistinguishable from wild-type
N Takahashi, MLSS Lopez, JE Cowhig Jr… - Journal of the …, 2005 - journals.lww.com
Mice lacking Ren1c were generated using C57BL/6-derived embryonic stem cells. Mice
homozygous for Ren1c disruption (Ren1c−/−) are born at the expected ratio, but
approximately 80% die of dehydration within a few days. The surviving Ren1c−/− mice have
no renin mRNA expression in the kidney, hydronephrosis, thickening of renal arterial walls,
and fibrosis in the kidney. Plasma renin and angiotensins I and II are undetectable. Urinary
aldosterone is 6% wild-type. They have low tail-cuff BP (84±4 versus 116±5 mmHg in+/+) …
homozygous for Ren1c disruption (Ren1c−/−) are born at the expected ratio, but
approximately 80% die of dehydration within a few days. The surviving Ren1c−/− mice have
no renin mRNA expression in the kidney, hydronephrosis, thickening of renal arterial walls,
and fibrosis in the kidney. Plasma renin and angiotensins I and II are undetectable. Urinary
aldosterone is 6% wild-type. They have low tail-cuff BP (84±4 versus 116±5 mmHg in+/+) …