Antidiuretic action of collecting duct (pro) renin receptor downstream of vasopressin and PGE2 receptor EP4

F Wang, X Lu, K Peng, H Fang, L Zhou… - Journal of the …, 2016 - journals.lww.com
Within the kidney, the (pro) renin receptor (PRR) is predominantly expressed in the
collecting duct (CD), particularly in intercalated cells, and it is regulated by the PGE 2
receptor EP 4. Notably, EP 4 also controls urinary concentration through regulation of
aquaporin 2 (AQP2). Here, we tested the hypothesis that sequential activation of EP 4 and
PRR determines AQP2 expression in the CD, thus mediating the antidiuretic action of
vasopressin (AVP). Water deprivation (WD) elevated renal PRR expression and urinary …