Background Single-cell genomics techniques are revolutionizing our ability to characterize
complex tissues. By contrast, the techniques used to analyze renal biopsy specimens have
changed little over several decades. We tested the hypothesis that single-cell RNA-
sequencing can comprehensively describe cell types and states in a human kidney biopsy
specimen. Methods We generated 8746 single-cell transcriptomes from a healthy adult
kidney and a single kidney transplant biopsy core by single-cell RNA-sequencing …