2-Methoxyestradiol deficiency is strongly related to hypertension in early onset severe pre-eclampsia

Y Zhang, T Wang, Y Shen, X Wang, PN Baker… - … An International Journal …, 2014 - Elsevier
Abstract Objective 2-Methoxyestradiol (2ME) deficiency leading to placental insufficiency
has been related to pre-eclampsia (PE). Here we investigate whether 2ME is related to
clinical profiles and vasoactive factors in early onset severe PE patients. Methods 28 severe
PE patients and 20 uncomplicated normal pregnant women, with gestational weeks
between 24 and 32 weeks, were recruited. All cases and controls had singleton pregnancies
and were matched for maternal age, parity, body mass index, and gestational weeks …