Tumor promoting role of anti-tumor macrophages in tumor microenvironment

KK Goswami, T Ghosh, S Ghosh, M Sarkar, A Bose… - Cellular …, 2017 - Elsevier
Recent advances in tumor biology demand detailed analysis of the complex interaction of
tumor cells with their adjacent microenvironment (tumor stroma) to understand the various
mechanisms involved in tumor growth and metastasis. Mononuclear phagocytes or
macrophages, a type of innate immune cells, defend the organism against infection and
injury. On the otherhand, tumor associated macrophages (TAMs) constitute a significant part
of the tumor-infiltrating immune cells, have been linked to the growth, angiogenesis, and …