[HTML][HTML] Serial measurements of phosphorylated neurofilament-heavy in the serum of subjects with amyotrophic lateral sclerosis
PA McCombe, C Pfluger, P Singh, CYH Lim… - Journal of the …, 2015 - Elsevier
There is a need for a blood biomarker of disease activity in ALS. This marker needs to
measure the loss of motor neurones. Phosphorylated neurofilament heavy chain (pNfH) in
the serum is a biomarker of axonal injury. Previous studies have found that levels of pNfH
are elevated in ALS. We have performed a serial study of pNfH levels in 98 subjects from our
ALS clinic. There was significant elevation of levels of pNfH in subjects with ALS compared
to controls, although there was considerable variability. In studies of individuals who had two …
measure the loss of motor neurones. Phosphorylated neurofilament heavy chain (pNfH) in
the serum is a biomarker of axonal injury. Previous studies have found that levels of pNfH
are elevated in ALS. We have performed a serial study of pNfH levels in 98 subjects from our
ALS clinic. There was significant elevation of levels of pNfH in subjects with ALS compared
to controls, although there was considerable variability. In studies of individuals who had two …