MYC/BCL2 co-expression is a stronger prognostic factor compared with the cell-of-origin classification in primary CNS DLBCL

QY Shi, X Feng, W Bao, J Ma, JH Lv… - … of Neuropathology & …, 2017 - academic.oup.com
QY Shi, X Feng, W Bao, J Ma, JH Lv, X Wang, Q Rao, QL Shi
Journal of Neuropathology & Experimental Neurology, 2017academic.oup.com
Primary central nervous system (CNS) diffuse large B-cell lymphoma (DLBCL) is a subtype
of DLBCL with an unfavorable prognosis and a poor response to the treatment. As we know,
DLBCL is stratified into germinal center B-cell (GCB)-like and activated B-cell (ABC)-like
subtypes with different prognosis according to their gene-expression characteristics. In this
study, we analyzed a case series of 77 patients with primary CNS DLBCL. A difference in
prognosis of GCB-like and ABC-like subtypes was noticed, but no statistical significance was …
Abstract
Primary central nervous system (CNS) diffuse large B-cell lymphoma (DLBCL) is a subtype of DLBCL with an unfavorable prognosis and a poor response to the treatment. As we know, DLBCL is stratified into germinal center B-cell (GCB)-like and activated B-cell (ABC)-like subtypes with different prognosis according to their gene-expression characteristics. In this study, we analyzed a case series of 77 patients with primary CNS DLBCL. A difference in prognosis of GCB-like and ABC-like subtypes was noticed, but no statistical significance was found. However, significant prognostic value of MYC/BCL2 co-expression was shown. The cases with MYC/BCL2 co-expression did not show any predominance of the 2 subtypes in our cases. Furthermore, patients with MYC/BCL2 co-expression had significantly worse overall survival for both cell of origin (COO) subtypes. We conjecture that MYC/BCL2 co-expression is associated with a poorer prognosis and is independent of COO classification. Moreover, the data suggest that MYC/BCL2 co-expression is superior to COO classification assessed by immunohistochemical analysis in patients with primary CNS DLBCL.
Oxford University Press