[HTML][HTML] On the origin of myeloid-derived suppressor cells

CR Millrud, C Bergenfelz, K Leandersson - Oncotarget, 2017 - ncbi.nlm.nih.gov
CR Millrud, C Bergenfelz, K Leandersson
Oncotarget, 2017ncbi.nlm.nih.gov
Myeloid-derived suppressor cells (MDSCs) have a strong immunosuppressive character that
allows them to regulate immune responses and hinder overt inflammatory responses. In
cancer, this leads to tumor immune evasion and disease progression. MDSCs come in at
least two forms: monocytic (Mo-MDSCs) and granulocytic (G-MDSCs). The classical
definition of MDSCs as immature myeloid cells blocked from differentiating has been
challenged by recent studies suggesting that Mo-MDSCs and G-MDSCs may represent …
Abstract
Myeloid-derived suppressor cells (MDSCs) have a strong immunosuppressive character that allows them to regulate immune responses and hinder overt inflammatory responses. In cancer, this leads to tumor immune evasion and disease progression. MDSCs come in at least two forms: monocytic (Mo-MDSCs) and granulocytic (G-MDSCs). The classical definition of MDSCs as immature myeloid cells blocked from differentiating has been challenged by recent studies suggesting that Mo-MDSCs and G-MDSCs may represent monocytes and granulocytes that have acquired immunosuppressive properties. The molecular mechanism behind their generation and their true origins are now widely debated. In this review we discuss the different proposed mechanisms of the generation of both types of MDSCs, with a special focus on human MDSCs in cancer.
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