[HTML][HTML] The tumor suppressor gene HIC1 (hypermethylated in cancer 1) is a sequence-specific transcriptional repressor: definition of its consensus binding sequence …
S Pinte, N Stankovic-Valentin, S Deltour… - Journal of Biological …, 2004 - ASBMB
HIC1 (hypermethylated in cancer 1) is a tumor suppressor gene located at chromosome
17p13. 3, a region frequently hypermethylated or deleted in human tumors and in a
contiguous-gene syndrome, the Miller-Dieker syndrome. HIC1 is a transcriptional repressor
containing five Krüppel-like C 2 H 2 zinc fingers and an N-terminal dimerization and
autonomous repression domain called BTB/POZ. Although some of the HIC1 transcriptional
repression mechanisms have been recently deciphered, target genes are still to be …
17p13. 3, a region frequently hypermethylated or deleted in human tumors and in a
contiguous-gene syndrome, the Miller-Dieker syndrome. HIC1 is a transcriptional repressor
containing five Krüppel-like C 2 H 2 zinc fingers and an N-terminal dimerization and
autonomous repression domain called BTB/POZ. Although some of the HIC1 transcriptional
repression mechanisms have been recently deciphered, target genes are still to be …