[HTML][HTML] The extracellular matrix and inflammation: fibromodulin activates the classical pathway of complement by directly binding C1q
A Sjöberg, P Önnerfjord, M Mörgelin… - Journal of Biological …, 2005 - ASBMB
Components that propagate inflammation in joint disease may be derived from cartilage
since the inflammation resolves after joint replacement. We found that the cartilage
component fibromodulin has the ability to activate an inflammatory cascade, ie complement.
Fibromodulin and immunoglobulins cause comparable deposition of C1q, C4b, and C3b
from human serum. Using C1q and factor B-deficient sera in combination with varying
contents of metal ions, we established that fibromodulin activates both the classical and the …
since the inflammation resolves after joint replacement. We found that the cartilage
component fibromodulin has the ability to activate an inflammatory cascade, ie complement.
Fibromodulin and immunoglobulins cause comparable deposition of C1q, C4b, and C3b
from human serum. Using C1q and factor B-deficient sera in combination with varying
contents of metal ions, we established that fibromodulin activates both the classical and the …