[HTML][HTML] Roles for the sarco-/endoplasmic reticulum in cardiac myocyte contraction, protein synthesis, and protein quality control
CC Glembotski - Physiology, 2012 - journals.physiology.org
Physiology, 2012•journals.physiology.org
Although the function of the sarcoplasmic/endoplasmic reticulum (SR/ER) in cardiac
contractile calcium handling is well established, its roles in protein synthesis, folding, and
quality control in cardiac myocytes are not as clear. This review explores evidence
suggesting that, in cardiac myocytes, protein synthesis and contractile calcium handling may
be physically and functionally integrated.
contractile calcium handling is well established, its roles in protein synthesis, folding, and
quality control in cardiac myocytes are not as clear. This review explores evidence
suggesting that, in cardiac myocytes, protein synthesis and contractile calcium handling may
be physically and functionally integrated.
Abstract
Although the function of the sarcoplasmic/endoplasmic reticulum (SR/ER) in cardiac contractile calcium handling is well established, its roles in protein synthesis, folding, and quality control in cardiac myocytes are not as clear. This review explores evidence suggesting that, in cardiac myocytes, protein synthesis and contractile calcium handling may be physically and functionally integrated.
American Physiological Society