Microglia in the immune surveillance of the brain: human microglia constitutively express HLA-DR molecules
J Gehrmann, RB Banati, GW Kreutzberg - Journal of neuroimmunology, 1993 - Elsevier
The degree of MHC class II expression in histologically normal human brain biopsy or
autopsy tissue is still controversial. According to the generally held view MHC class II
expression is rather low in the normal brain with the exception of the white matter. In the
present study, HLA-DR expression was examined immunocytochemically in different brain
areas obtained from three autopsy cases with short post-mortem times (ie 6 h). Based on
standard histological evaluation, the brain areas studied appeared as histologically normal …
autopsy tissue is still controversial. According to the generally held view MHC class II
expression is rather low in the normal brain with the exception of the white matter. In the
present study, HLA-DR expression was examined immunocytochemically in different brain
areas obtained from three autopsy cases with short post-mortem times (ie 6 h). Based on
standard histological evaluation, the brain areas studied appeared as histologically normal …