HIF-1α induction suppresses excessive lipid accumulation in alcoholic fatty liver in mice
Y Nishiyama, N Goda, M Kanai, D Niwa, K Osanai… - Journal of …, 2012 - Elsevier
BACKGROUND & AIMS: Chronic alcohol intake stimulates hepatic oxygen consumption and
subsequently causes liver hypoxia, leading to activation of hypoxia inducible factor-1 (HIF-
1). Although HIF-1 plays a crucial role in the metabolic switch from aerobic to anaerobic
metabolism in response to hypoxia, its roles in the regulation of lipid metabolism in alcoholic
fatty liver remain unknown. METHODS: Wild-type and hepatocyte-specific HIF-1α-null mice
were subjected to a 6% ethanol-containing liquid diet for 4weeks, and functional effects of …
subsequently causes liver hypoxia, leading to activation of hypoxia inducible factor-1 (HIF-
1). Although HIF-1 plays a crucial role in the metabolic switch from aerobic to anaerobic
metabolism in response to hypoxia, its roles in the regulation of lipid metabolism in alcoholic
fatty liver remain unknown. METHODS: Wild-type and hepatocyte-specific HIF-1α-null mice
were subjected to a 6% ethanol-containing liquid diet for 4weeks, and functional effects of …