[HTML][HTML] Adipose tissue-specific inhibition of hypoxia-inducible factor 1α induces obesity and glucose intolerance by impeding energy expenditure in mice
Hypoxia in adipose tissue has been postulated as a possible contributor to obesity-related
chronic inflammation, insulin resistance, and metabolic dysfunction. HIF1α (hypoxia-
inducible factor 1α), a master signal mediator of hypoxia response, is elevated in obese
adipose tissue. However, the role of HIF1α in obesity-related pathologies remains to be
determined. Here we show that transgenic mice with adipose tissue-selective expression of
a dominant negative version of HIF1α developed more severe obesity and were more …
chronic inflammation, insulin resistance, and metabolic dysfunction. HIF1α (hypoxia-
inducible factor 1α), a master signal mediator of hypoxia response, is elevated in obese
adipose tissue. However, the role of HIF1α in obesity-related pathologies remains to be
determined. Here we show that transgenic mice with adipose tissue-selective expression of
a dominant negative version of HIF1α developed more severe obesity and were more …