[HTML][HTML] Hypoxia increases sirtuin 1 expression in a hypoxia-inducible factor-dependent manner
R Chen, EM Dioum, RT Hogg, RD Gerard… - Journal of Biological …, 2011 - ASBMB
Hypoxia-inducible factors (HIFs) are stress-responsive transcriptional regulators of cellular
and physiological processes involved in oxygen metabolism. Although much is understood
about the molecular machinery that confers HIF responsiveness to oxygen, far less is known
about HIF isoform-specific mechanisms of regulation, despite the fact that HIF-1 and HIF-2
exhibit distinct biological roles. We recently determined that the stress-responsive genetic
regulator sirtuin 1 (Sirt1) selectively augments HIF-2 signaling during hypoxia. However, the …
and physiological processes involved in oxygen metabolism. Although much is understood
about the molecular machinery that confers HIF responsiveness to oxygen, far less is known
about HIF isoform-specific mechanisms of regulation, despite the fact that HIF-1 and HIF-2
exhibit distinct biological roles. We recently determined that the stress-responsive genetic
regulator sirtuin 1 (Sirt1) selectively augments HIF-2 signaling during hypoxia. However, the …