Hematopoietic microRNA-126 protects against renal ischemia/reperfusion injury by promoting vascular integrity
R Bijkerk, C van Solingen, HC de Boer… - Journal of the …, 2014 - journals.lww.com
Ischemia/reperfusion injury (IRI) is a central phenomenon in kidney transplantation and AKI.
Integrity of the renal peritubular capillary network is an important limiting factor in the
recovery from IRI. MicroRNA-126 (miR-126) facilitates vascular regeneration by functioning
as an angiomiR and by modulating mobilization of hematopoietic stem/progenitor cells. We
hypothesized that overexpression of miR-126 in the hematopoietic compartment could
protect the kidney against IRI via preservation of microvascular integrity. Here, we …
Integrity of the renal peritubular capillary network is an important limiting factor in the
recovery from IRI. MicroRNA-126 (miR-126) facilitates vascular regeneration by functioning
as an angiomiR and by modulating mobilization of hematopoietic stem/progenitor cells. We
hypothesized that overexpression of miR-126 in the hematopoietic compartment could
protect the kidney against IRI via preservation of microvascular integrity. Here, we …