Regulation of renal tubular cell apoptosis and proliferation after ischemic injury to a solitary kidney

R Oberbauer, C Schwarz, HM Regele… - Journal of Laboratory …, 2001 - Elsevier
The time course and regulation of apoptosis and cellular regeneration after 30 minutes of
acute ischemic injury to a single kidney was elucidated in rats at five time points over 20
weeks. The fraction of apoptotic cells was most prominent at 1 day after the insult in the
distal tubule (8%±4% vs 0%±0%, acute renal failure [ARF] vs sham, respectively) and was
still elevated at 7 days (2%±2% vs 0%±0%). At that time, the whole kidney mRNA
expression of the apoptosis inhibitory genes bcl-xL and bcl-2, as well as that of the …