[HTML][HTML] Nucleophosmin/B23 is a candidate substrate for the BRCA1-BARD1 ubiquitin ligase
K Sato, R Hayami, W Wu, T Nishikawa… - Journal of Biological …, 2004 - ASBMB
The breast and ovarian tumor suppressor BRCA1 forms a heterodimeric RING-type ubiquitin
ligase with BARD1 to catalyze untraditional Lys-6-linked polyubiquitin chains. It is not clear
how the BRCA1-BARD1 ligase regulates various cellular processes such as DNA repair,
cell-cycle progression, transcriptional regulation, and centrosome duplication. Here we
report that BRCA1-BARD1 catalyzes the polyubiquitination of nucleolar phosphoprotein
nucleophosmin/B23 (NPM). Two different mass spectrometry screens for protein …
ligase with BARD1 to catalyze untraditional Lys-6-linked polyubiquitin chains. It is not clear
how the BRCA1-BARD1 ligase regulates various cellular processes such as DNA repair,
cell-cycle progression, transcriptional regulation, and centrosome duplication. Here we
report that BRCA1-BARD1 catalyzes the polyubiquitination of nucleolar phosphoprotein
nucleophosmin/B23 (NPM). Two different mass spectrometry screens for protein …