Hepcidin as a major component of renal antibacterial defenses against uropathogenic Escherichia coli
D Houamel, N Ducrot, T Lefebvre… - Journal of the …, 2016 - journals.lww.com
The iron-regulatory peptide hepcidin exhibits antimicrobial activity. Having previously shown
hepcidin expression in the kidney, we addressed its role in urinary tract infection (UTI),
which remains largely unknown. Experimental UTI was induced in wild-type (WT) and
hepcidin-knockout (Hepc−/−) mice using the uropathogenic Escherichia coli CFT073 strain.
Compared with infected WT mice, infected Hepc−/− mice showed a dramatic increase in
renal bacterial load. Moreover, bacterial invasion was significantly dampened by the …
hepcidin expression in the kidney, we addressed its role in urinary tract infection (UTI),
which remains largely unknown. Experimental UTI was induced in wild-type (WT) and
hepcidin-knockout (Hepc−/−) mice using the uropathogenic Escherichia coli CFT073 strain.
Compared with infected WT mice, infected Hepc−/− mice showed a dramatic increase in
renal bacterial load. Moreover, bacterial invasion was significantly dampened by the …