[HTML][HTML] Characterization of a novel intestinal glycerol-3-phosphate acyltransferase pathway and its role in lipid homeostasis

I Khatun, RW Clark, NB Vera, K Kou, DM Erion… - Journal of Biological …, 2016 - ASBMB
Dietary triglycerides (TG) are absorbed by the enterocytes of the small intestine after luminal
hydrolysis into monacylglycerol and fatty acids. Before secretion on chylomicrons, these
lipids are reesterified into TG, primarily through the monoacylglycerol pathway. However,
targeted deletion of the primary murine monoacylglycerol acyltransferase does not
quantitatively affect lipid absorption, suggesting the existence of alternative pathways.
Therefore, we investigated the role of the glycerol 3-phosphate pathway in dietary lipid …