[HTML][HTML] Complexity in the secretory pathway: the assembly and secretion of apolipoprotein B-containing lipoproteins
EA Fisher, HN Ginsberg - Journal of Biological Chemistry, 2002 - ASBMB
Apolipoprotein B100 (apoB100) is expressed primarily in mammalian liver. It has 4536
amino acids, 25 cysteines (16 of which are in intramolecular disulfide bonds), and 20 N-
linked glycosylation sites. A smaller form, apoB48, is expressed in mammalian intestine and
in the livers of some non-human mammals. ApoB48 results from a post-transcriptional
modification of the apoB mRNA at codon 2153 that converts a glutamine codon to a stop
codon at 48% of the full-length coding sequence. Both forms of apoB have a complex …
amino acids, 25 cysteines (16 of which are in intramolecular disulfide bonds), and 20 N-
linked glycosylation sites. A smaller form, apoB48, is expressed in mammalian intestine and
in the livers of some non-human mammals. ApoB48 results from a post-transcriptional
modification of the apoB mRNA at codon 2153 that converts a glutamine codon to a stop
codon at 48% of the full-length coding sequence. Both forms of apoB have a complex …