[HTML][HTML] Glucocorticoids and cyclic AMP selectively increase hepatic lipin-1 expression, and insulin acts antagonistically
B Manmontri, M Sariahmetoglu, J Donkor… - Journal of lipid …, 2008 - ASBMB
Glucocorticoids (GCs) increase hepatic phosphatidate phosphatase (PAP1) activity. This is
important in enhancing the liver's capacity for storing fatty acids as triacylglycerols (TAGs)
that can be used subsequently for β-oxidation or VLDL secretion. PAP1 catalyzes the
conversion of phosphatidate to diacylglycerol, a key substrate for TAG and phospholipid
biosynthesis. PAP1 enzymes in liver include lipin-1A and-1B (alternatively spliced isoforms)
and two distinct gene products, lipin-2 and lipin-3. We determined the mechanisms by which …
important in enhancing the liver's capacity for storing fatty acids as triacylglycerols (TAGs)
that can be used subsequently for β-oxidation or VLDL secretion. PAP1 catalyzes the
conversion of phosphatidate to diacylglycerol, a key substrate for TAG and phospholipid
biosynthesis. PAP1 enzymes in liver include lipin-1A and-1B (alternatively spliced isoforms)
and two distinct gene products, lipin-2 and lipin-3. We determined the mechanisms by which …