Hippocampal neuron damage in human epilepsy: Meyer's hypothesis revisited

GW Mathern, PD Adelson, LD Cahan, JP Leite - Progress in brain research, 2002 - Elsevier
Whether hippocampal neuron loss and/or hippocampal sclerosis is the 'cause'or
'consequence'of seizures has been a fundamental question in human epilepsy studies for
over a century. To address this question, this study examined hippocampal specimens from
temporal lobe epilepsy patients (TLE; n= 572) and those with extra-temporal seizures and
pathologies (n= 73) for qualitative signs of hippocampal sclerosis and quantitative neuron
loss using cell counting techniques. Patients were additionally classified based on …