Combined magnetic resonance elastography and collagen molecular magnetic resonance imaging accurately stage liver fibrosis in a rat model
Hepatic fibrosis is associated with an overproduction of matrix proteins and a pathological
increase of liver stiffness. Noninvasive magnetic resonance (MR) quantification of matrix can
be assessed with a collagen‐binding molecular MR probe and stiffness by MR
elastography, complementary techniques. This study used both imaging techniques to more
accurately stage hepatic fibrosis in a rat model. Thirty rats with varying levels of
diethylnitrosamine‐induced liver fibrosis were imaged before and 45 minutes after injection …
increase of liver stiffness. Noninvasive magnetic resonance (MR) quantification of matrix can
be assessed with a collagen‐binding molecular MR probe and stiffness by MR
elastography, complementary techniques. This study used both imaging techniques to more
accurately stage hepatic fibrosis in a rat model. Thirty rats with varying levels of
diethylnitrosamine‐induced liver fibrosis were imaged before and 45 minutes after injection …