[HTML][HTML] p110δ, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes
D Chantry, A Vojtek, A Kashishian, DA Holtzman… - Journal of Biological …, 1997 - ASBMB
We have identified a novel p110 isoform of phosphatidylinositol 3-kinase from human
leukocytes that we have termed p110δ. In addition, we have independently isolated p110δ
from a mouse embryo library on the basis of its ability to interact with Ha-Ras V12 in the
yeast two-hybrid system. This unique isoform contains all of the conserved structural
features characteristic of the p110 family. Recombinant p110δ phosphorylates
phosphatidylinositol and coimmunoprecipitates with p85. However, in contrast to previously …
leukocytes that we have termed p110δ. In addition, we have independently isolated p110δ
from a mouse embryo library on the basis of its ability to interact with Ha-Ras V12 in the
yeast two-hybrid system. This unique isoform contains all of the conserved structural
features characteristic of the p110 family. Recombinant p110δ phosphorylates
phosphatidylinositol and coimmunoprecipitates with p85. However, in contrast to previously …