Degradation and beyond: the macrophage lysosome as a nexus for nutrient sensing and processing in atherosclerosis
Lysosomes are a central organelle in the processing of exogenous and intracellular
biomolecules. Together with recent data that implicate the degradation products of
lysosomes in modulation of signalling pathways, these organelles truly do lay at a nexus in
nutrient sensing and processing. Dissecting the full repertoire of lysosome function and
ensuing dysfunction in plaque macrophages is pivotal to our understanding of
atherogenesis.
biomolecules. Together with recent data that implicate the degradation products of
lysosomes in modulation of signalling pathways, these organelles truly do lay at a nexus in
nutrient sensing and processing. Dissecting the full repertoire of lysosome function and
ensuing dysfunction in plaque macrophages is pivotal to our understanding of
atherogenesis.
Summary
Lysosomes are a central organelle in the processing of exogenous and intracellular biomolecules. Together with recent data that implicate the degradation products of lysosomes in modulation of signalling pathways, these organelles truly do lay at a nexus in nutrient sensing and processing. Dissecting the full repertoire of lysosome function and ensuing dysfunction in plaque macrophages is pivotal to our understanding of atherogenesis.
Lippincott Williams & Wilkins