[HTML][HTML] The pioneer round of translation: features and functions
LE Maquat, WY Tarn, O Isken - Cell, 2010 - cell.com
LE Maquat, WY Tarn, O Isken
Cell, 2010•cell.comIn mammalian cells, newly synthesized mRNAs undergo a pioneer round of translation that
is important for mRNA quality control. Following maturation of messenger ribonucleoprotein
particles during and after the pioneer round, steady-state cycles of mRNA translation
generate most of the cell's proteins. Translation factors, RNA-binding proteins, and targets of
signaling pathways that are particular to newly synthesized mRNAs regulate critical
functions of the pioneer round.
is important for mRNA quality control. Following maturation of messenger ribonucleoprotein
particles during and after the pioneer round, steady-state cycles of mRNA translation
generate most of the cell's proteins. Translation factors, RNA-binding proteins, and targets of
signaling pathways that are particular to newly synthesized mRNAs regulate critical
functions of the pioneer round.
In mammalian cells, newly synthesized mRNAs undergo a pioneer round of translation that is important for mRNA quality control. Following maturation of messenger ribonucleoprotein particles during and after the pioneer round, steady-state cycles of mRNA translation generate most of the cell's proteins. Translation factors, RNA-binding proteins, and targets of signaling pathways that are particular to newly synthesized mRNAs regulate critical functions of the pioneer round.
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