[HTML][HTML] A conserved serine residue is required for the phosphatidate phosphatase activity but not the transcriptional coactivator functions of lipin-1 and lipin-2
J Donkor, P Zhang, S Wong, L O'Loughlin… - Journal of Biological …, 2009 - ASBMB
Mammalian lipins (lipin-1, lipin-2, and lipin-3) are Mg 2+-dependent phosphatidate
phosphatase (PAP) enzymes, which catalyze a key reaction in glycerolipid biosynthesis.
Lipin-1 also functions as a transcriptional coactivator in conjunction with members of the
peroxisome proliferator-activated receptor family. An S734L mutation in LPIN2 causes
Majeed syndrome, a human inflammatory disorder characterized by recurrent osteomyelitis,
fever, dyserythropoietic anemia, and cutaneous inflammation. Here we demonstrate that …
phosphatase (PAP) enzymes, which catalyze a key reaction in glycerolipid biosynthesis.
Lipin-1 also functions as a transcriptional coactivator in conjunction with members of the
peroxisome proliferator-activated receptor family. An S734L mutation in LPIN2 causes
Majeed syndrome, a human inflammatory disorder characterized by recurrent osteomyelitis,
fever, dyserythropoietic anemia, and cutaneous inflammation. Here we demonstrate that …