[HTML][HTML] Regulation of ERGIC-53 gene transcription in response to endoplasmic reticulum stress

M Renna, MG Caporaso, S Bonatti, RJ Kaufman… - Journal of Biological …, 2007 - ASBMB
Accumulation of unfolded proteins within the endoplasmic reticulum (ER) activates the
unfolded protein response, also known as the ER stress response. We previously
demonstrated that ER stress induces transcription of the ER Golgi intermediate compartment
protein ERGIC-53. To investigate the molecular events that regulate unfolded protein
response-mediated induction of the gene, we have analyzed the transcriptional regulation of
ERGIC-53. We found that the ERGIC-53 promoter contains a single cis-acting element that …