Unmasking recurrent excitation generated by mossy fiber sprouting in the epileptic dentate gyrus: an emergent property of a complex system
TP Sutula, FE Dudek - Progress in brain research, 2007 - Elsevier
Seizure-induced sprouting of the mossy fiber pathway in the dentate gyrus has been
observed nearly universally in experimental models of limbic epilepsy and in the epileptic
human hippocampus. The observation of progressive mossy fiber sprouting induced by
kindling demonstrated that even a few repeated seizures are sufficient to alter synaptic
connectivity and circuit organization. As it is now recognized that seizures induce synaptic
reorganization in hippocampal and cortical pathways, the implications of seizure-induced …
observed nearly universally in experimental models of limbic epilepsy and in the epileptic
human hippocampus. The observation of progressive mossy fiber sprouting induced by
kindling demonstrated that even a few repeated seizures are sufficient to alter synaptic
connectivity and circuit organization. As it is now recognized that seizures induce synaptic
reorganization in hippocampal and cortical pathways, the implications of seizure-induced …