[HTML][HTML] Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5
H Kurooka, T Honjo - Journal of Biological Chemistry, 2000 - ASBMB
The Notch receptor that plays an important role in cell fate determination is intracellularly
cleaved by interaction with the ligand. The cleaved intracellular region (RAMIC) of Notch is
translocated into the nucleus and interacts with a DNA-binding protein RBP-J to activate
transcription of genes that regulate cell differentiation. Although RAMIC has been shown to
facilitate the RBP-J-mediated transactivation by displacing the histone deacetylase
corepressor complex from RBP-J, there is no evidence demonstrating the involvement of …
cleaved by interaction with the ligand. The cleaved intracellular region (RAMIC) of Notch is
translocated into the nucleus and interacts with a DNA-binding protein RBP-J to activate
transcription of genes that regulate cell differentiation. Although RAMIC has been shown to
facilitate the RBP-J-mediated transactivation by displacing the histone deacetylase
corepressor complex from RBP-J, there is no evidence demonstrating the involvement of …