[HTML][HTML] Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans
DK Hagman, LB Hays, SD Parazzoli… - Journal of Biological …, 2005 - ASBMB
Abnormalities in lipid metabolism have been proposed as contributing factors to both
defective insulin secretion from the pancreatic beta cell and peripheral insulin resistance in
type 2 diabetes. Previously, we have shown that prolonged exposure of isolated rat islets of
Langerhans to excessive fatty acid levels impairs insulin gene transcription. This study was
designed to assess whether palmitate alters the expression and binding activity of the key
regulatory factors pancreas-duodenum homeobox-1 (PDX-1), MafA, and Beta2, which …
defective insulin secretion from the pancreatic beta cell and peripheral insulin resistance in
type 2 diabetes. Previously, we have shown that prolonged exposure of isolated rat islets of
Langerhans to excessive fatty acid levels impairs insulin gene transcription. This study was
designed to assess whether palmitate alters the expression and binding activity of the key
regulatory factors pancreas-duodenum homeobox-1 (PDX-1), MafA, and Beta2, which …