Bispecific antibodies may be used to improve clinical efficacy by targeting two disease
mechanisms for the treatment of complex human diseases in a single agent. Bispecific
antibodies also hold promise for certain therapeutic applications difficult to achieve by single-
targeting monospecific antibodies, such as immune (T cell or NK) cell retargeting, site-
specific targeting, enabling therapeutics to cross the blood–brain barrier, and unique
receptor modulation. Although the history of bispecific antibody research is almost as long …