Translation: screening for novel therapeutics with disease-relevant cell types derived from human stem cell models
SJ Haggarty, RH Perlis - Biological psychiatry, 2014 - Elsevier
The advent of somatic cell reprogramming technologies—which enables the generation of
patient-specific, induced pluripotent stem cell and other trans-differentiated human neuronal
cell models—provides new means of gaining insight into the molecular mechanisms and
neural substrates of psychiatric disorders. By allowing a more precise understanding of
genotype-phenotype relationship in disease-relevant human cell types, the use of
reprogramming technologies in tandem with emerging genome engineering approaches …
patient-specific, induced pluripotent stem cell and other trans-differentiated human neuronal
cell models—provides new means of gaining insight into the molecular mechanisms and
neural substrates of psychiatric disorders. By allowing a more precise understanding of
genotype-phenotype relationship in disease-relevant human cell types, the use of
reprogramming technologies in tandem with emerging genome engineering approaches …