Interactions between renin angiotensin system and advanced glycation in the kidney
MC Thomas, C Tikellis, WM Burns… - Journal of the …, 2005 - journals.lww.com
Although hemodynamic and metabolic factors are individually implicated in the development
of diabetic nephropathy, their interaction has not been defined clearly. In this study, the
effects of angiotensin II (Ang II) and advanced glycation end products (AGE) both
individually on each other are explored and compared. In the first study arm, Sprague-
Dawley rats received a continuous infusion of AGE-modified rat serum albumin (RSA) or
unmodified RSA for 4 wk with or without the angiotensin receptor type 1 antagonist …
of diabetic nephropathy, their interaction has not been defined clearly. In this study, the
effects of angiotensin II (Ang II) and advanced glycation end products (AGE) both
individually on each other are explored and compared. In the first study arm, Sprague-
Dawley rats received a continuous infusion of AGE-modified rat serum albumin (RSA) or
unmodified RSA for 4 wk with or without the angiotensin receptor type 1 antagonist …