Elimination mechanisms of therapeutic monoclonal antibodies
MA Tabrizi, CML Tseng, LK Roskos - Drug discovery today, 2006 - Elsevier
MA Tabrizi, CML Tseng, LK Roskos
Drug discovery today, 2006•ElsevierTargeted therapies using monoclonal antibodies have achieved important therapeutic
applications in the treatment of various human diseases. Understanding the factors that
impact the pharmacokinetics of monoclonal antibodies is of high importance for effective
therapy. Many factors related to the target antigen, antibody and patients can affect antibody
elimination. Evaluation of these factors will facilitate the understanding of the processes
involved in antibody elimination.
applications in the treatment of various human diseases. Understanding the factors that
impact the pharmacokinetics of monoclonal antibodies is of high importance for effective
therapy. Many factors related to the target antigen, antibody and patients can affect antibody
elimination. Evaluation of these factors will facilitate the understanding of the processes
involved in antibody elimination.
Targeted therapies using monoclonal antibodies have achieved important therapeutic applications in the treatment of various human diseases. Understanding the factors that impact the pharmacokinetics of monoclonal antibodies is of high importance for effective therapy. Many factors related to the target antigen, antibody and patients can affect antibody elimination. Evaluation of these factors will facilitate the understanding of the processes involved in antibody elimination.
Elsevier